Mixed-donor faecal microbiota transplantation was associated with increased butyrate-producing bacteria for obesity

We read with interest the recent article by Haifer et al (Gut, 2022, 2022–3 27 742), which reported that donor gut microbiome stability and species evenness were associated with higher donor species engraftment in patients with UC following faecal microbiota transplantation (FMT). This has brought us one step closer towards the selection of optimal FMT donors. However, the high prevalence of extended-spectrum beta-lactamase organisms and the COVID-19 pandemic have restricted the recruitment of FMT donors.1 An alternative means to increase the stability and species evenness is to pool the stool samples from multiple eligible FMT donors, which has been shown to be associated with higher clinical efficacy in UC.2 In obesity-related metabolic disorders, outcomes following FMT have been variable.3–8 Although the underlying mechanisms are unclear, the efficacy of FMT is likely to be affected by...

Source: Gut - April 5, 2024 Category: Gastroenterology Authors: Xu, Z., Mak, J. W. Y., Lin, Y., Yang, K., Liu, Q., Zhang, F., Lau, L., Tang, W., Ching, J. Y., Tun, H. M., Chan, P., Chan, F. K. L., Ng, S. C. Tags: Gut PostScript Source Type: research