Toning down the role of eosinophils in eosinophilic oesophagitis

Eosinophilic oesophagitis (EoE) is an immune-mediated disease of uncertain aetiology. The diagnosis of EoE relies on the epithelial infiltration of eosinophils (peak eosinophil count of ≥15 per high-power field (HPF)) and on the presence of symptoms. Consequently, a combined clinical–histological endpoint has been devised to assess response to treatments in clinical trials. Recent guidelines drafted by the British Society of Gastroenterology have confirmed the pivotal role of swallowed topical steroid and, for the first time, explicitly considered the use of biological therapy in case of a coexisting severe allergic condition.1 These guidelines have appraised the results of pivotal trials leading to the approval of orodispersible budesonide and dupilumab, a monoclonal antibody targeting interleukin (IL)-14 and IL-13, since they both met the aforementioned coprimary endpoint.2 3 Additionally, dupilumab also proved to enhance distensibility of the oesophagus wall. These results, along with the proved efficacy...
Source: Gut - Category: Gastroenterology Authors: Tags: Gut PostScript Source Type: research