BODIPY phototether enables oligonucleotide cyclization and subsequent deprotection by tissue-transparent red light

Chem Commun (Camb). 2024 Apr 2. doi: 10.1039/d4cc00272e. Online ahead of print.ABSTRACTmeso-methyl-BODIPY photocages release a leaving group upon visible light irradiation but often lack thermal stability. In turn, our thermally-stable, red-shifted BODIPY phototether allows oligonucleotide cyclization, preventing complementary strand hybridization. Hybridization resumes upon red-NIR irradiation, disconnecting the phototether by oxidative cleavage, which is easily monitored by a blue shift in fluorescence.PMID:38563214 | DOI:10.1039/d4cc00272e

Source: Chemical Communications - April 2, 2024 Category: Chemistry Authors: Lucie Wohlr ábová Marlen Sahlbach Alexander Heckel Tom áš Slanina Source Type: research