Photoredox-catalyzed radical-radical cross coupling of ketyl radicals with unstabilized primary alkyl radicals

Chem Commun (Camb). 2024 Apr 2. doi: 10.1039/d4cc00620h. Online ahead of print.ABSTRACTHerein, a novel protocol dealing with the preparation of sterically hindered alcohols has been successfully developed via radical-radical coupling reactions enabled by mild and redox-neutral photocatalysis. With alkylsilicates as the radical precursors, a range of primary alkyl radicals bearing various functional groups could couple with a range of phthalimides and activated ketones.PMID:38563261 | DOI:10.1039/d4cc00620h

Source: Chemical Communications - April 2, 2024 Category: Chemistry Authors: Shishen Feng Hong Liu Yan Li Yewen Fang Source Type: research