Maximum a posteriori Bayesian methods out-perform non-compartmental analysis for busulfan precision dosing

In conclusion, although AUC estimates between the two methods showed good correlation, in a simulated study, MAP lead to higher target attainment. When changing from one method to another, or changing infusion duration and oth er factors, optimum estimated exposure targets may require adjusting to maintain a consistent exposure.
Source: Journal of Pharmacokinetics and Pharmacodynamics - Category: Drugs & Pharmacology Source Type: research