Dissection of a CTCF topological boundary uncovers principles of enhancer-oncogene regulation

Enhancer-gene communication is dependent on chromosome topology, which helps enhancers find their correct gene targets. Kim et  al. characterize topological boundaries that insulate the oncogenes FGF3 and FGF4 from a potent enhancer and show that combinatorial disruption of CTCF sites in the boundary results in enhancer-promoter contact and gene induction.

Source: Molecular Cell - March 6, 2024 Category: Cytology Authors: Kyung Lock Kim, Gilbert J. Rahme, Viraat Y. Goel, Chadi A. El Farran, Anders S. Hansen, Bradley E. Bernstein Tags: Short article Source Type: research