27. Combinatory effects of unilateral oophorectomy plus cyclophosphamide treatment on ovarian reserve and fertility in a mouse model

Ovarian tissue cryopreservation via unilateral oophorectomy (ooph) prior to receiving gonadotoxic treatment is the gold standard for fertility preservation in pre-pubertal girls. The deleterious effects of cyclophosphamide (Cy) on ovarian follicles have been well studied, but it is not known how unilateral ooph in combination with Cy may influence ovarian function and risk of premature ovarian insufficiency. The aim of this study was to investigate the combined effects of unilateral ooph  + Cy on AMH and ovarian follicles using a mouse model.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research