11. Possible compensatory mechanisms of follicle protection in the retained ovary after unilateral oophorectomy in mouse models
In women who undergo unilateral oophorectomy (UO), some studies have shown that spontaneous pregnancy rates are similar to those who still have both ovaries intact. Furthermore, women who underwent UO entered menopause approximately 1 year earlier than those who have both ovaries, suggesting a compensatory mechanism. Since these effects are lower than what would be expected from the loss of half of the ovarian reserve, the aim of this study was to investigate possible compensatory mechanisms of follicle protection in the retained ovary after UO in mouse models.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Elizabeth Varghese, Taylor Badger, Raghuveer Kavarthapu, Alexander Grinberg, Ramya Balasubramanian, Hong Lou, Maria De La Luz Sierra, Karl Pfeifer, Jacqueline Maher, Veronica Gomez-Lobo Source Type: research