Synthesis of tetrahydroquinazolines from 2-aminobenzonitriles and alkylidene malonates < em > via < /em > 1,4-conjugate addition and an unprecedented rearrangement reaction

Chem Commun (Camb). 2024 Mar 28. doi: 10.1039/d4cc00240g. Online ahead of print.ABSTRACTAn efficient methodology for the synthesis of highly diverse tetrahydroquinazoline scaffolds from 2-aminobenzonitriles and alkylidene malonates via 1,4-conjugate addition followed by an unprecedented rearrangement has been demonstrated. The methodology is further applicable for the synthesis of quinazolines and tetracyclic compounds. Some of the synthesized compounds exhibit photophysical properties.PMID:38547001 | DOI:10.1039/d4cc00240g

Source: Chemical Communications - March 28, 2024 Category: Chemistry Authors: Bikoshita Porashar Bipin Kumar Behera Hunmoina Phukon Anil K Saikia Source Type: research