Histological differences between the central and peripheral areas of the testes of busulfan-administered mice

In this study, busulfan was intraperitoneally injected at 40 mg/kg body weight into C57BL/6J male mice. After 28 days, in busulfan-treated mice, the diameters of seminiferous tubules were significantly higher in the central than in the peripheral area of the testes. The seminiferous tubular areas also significantly decreased in the peripheral areas compared with the central areas. The number of germ cells per seminiferous tubule was significantly higher in the central than in the peripheral area. Sertoli cell nuclei were detached into the lumen in the peripheral area. The number of Leydig cells was significantly lower in the peripheral areas. These data suggest that the effects of busulfan differ between the central and peripheral areas of the testis at 4 weeks after busulfan administration.PMID:38556351 | DOI:10.2131/jts.49.139

Source: Journal of Toxicological Sciences - March 31, 2024 Category: Toxicology Authors: Hidenobu Miyaso Satoshi Yokota Kousuke Suga Yui Hashimoto C éline Kouno Kenta Nagahori Masahiro Itoh Satoshi Kitajima Source Type: research