Biphasic modulation of tau liquid-liquid phase separation by polyphenols

Chem Commun (Camb). 2024 Mar 28. doi: 10.1039/d4cc00473f. Online ahead of print.ABSTRACTMolecular tools that modulate tau liquid-liquid phase separation (LLPS) promise to treat tauopathies. We screened a set of polyphenols and demonstrated concentration-dependent biphasic modulation of tau LLPS by gallic acid (GA), showcasing its ability to expedite the liquid-to-gel transition in tau condensates and effectively impede the formation of deleterious fibrillar aggregates.PMID:38545836 | DOI:10.1039/d4cc00473f

Source: Chemical Communications - March 28, 2024 Category: Chemistry Authors: Hariharan Moorthy Nimsha Kamala Madhu Ramesh Thimmaiah Govindaraju Source Type: research