Synthesis of two nitrogen-containing polyaromatic compounds through gold catalysis/DBU-promoted cyclizations

Chem Commun (Camb). 2024 Mar 28. doi: 10.1039/d4cc00113c. Online ahead of print.ABSTRACTThis work reports an efficient synthesis of novel benzo[7,8]indolizino[2,3,4,5-ija]quinazoline derivatives between 2-(2-ethynylaryl)acetonitriles 1 and anthranils 2. The synthetic approach involves the initial formation of 7-formylindole intermediates that can be implemented by DBU to activate a novel indole-nitrile-aldehyde cyclization.PMID:38546213 | DOI:10.1039/d4cc00113c

Source: Chemical Communications - March 28, 2024 Category: Chemistry Authors: Vikas Ashokrao Sadaphal Tien-Lin Wu Rai-Shung Liu Source Type: research