Optimal futility stopping boundaries for binary endpoints

Group sequential designs incorporating the option to stop for futility at the time point of an interim analysis can save time and resources. Thereby, the choice of the futility boundary importantly impacts the...

Source: BMC Medical Research Methodology - March 28, 2024 Category: Research Authors: Michaela  Maria Freitag, Xieran Li and Geraldine Rauch Tags: Research Source Type: research