Spatial omics techniques and data analysis for cancer immunotherapy applications
Curr Opin Biotechnol. 2024 Mar 22;87:103111. doi: 10.1016/j.copbio.2024.103111. Online ahead of print.ABSTRACTIn-depth profiling of cancer cells/tissues is expanding our understanding of the genomic, epigenomic, transcriptomic, and proteomic landscape of cancer. However, the complexity of the cancer microenvironment, particularly its immune regulation, has made it difficult to exploit the potential of cancer immunotherapy. High-throughput spatial omics technologies and analysis pipelines have emerged as powerful tools for tackling this challenge. As a result, a potential revolution in cancer diagnosis, prognosis, and treatment is on the horizon. In this review, we discuss the technological advances in spatial profiling of cancer around and beyond the central dogma to harness the full benefits of immunotherapy. We also discuss the promise and challenges of spatial data analysis and interpretation and provide an outlook for the future.PMID:38520821 | DOI:10.1016/j.copbio.2024.103111
Source: Current Opinion in Biotechnology - Category: Biotechnology Authors: Yue Zhang Ren Yuan Lee Chin Wee Tan Xue Guo Willa W-Y Yim Jeffrey Ct Lim Felicia Yt Wee W U Yang Malvika Kharbanda Jia-Ying J Lee Nye Thane Ngo Wei Qiang Leow Lit-Hsin Loo Tony Kh Lim Radoslaw M Sobota Mai Chan Lau Melissa J Davis Joe Yeong Source Type: research