A practical guide for the preparation of C1-labeled α-amino acids using aldehyde catalysis with isotopically labeled CO2

Nature Protocols, Published online: 28 March 2024; doi:10.1038/s41596-024-00974-4Isotopically labeled amino acids are useful in pharmacology and for medical imaging. In this protocol, C1-labeled α-amino acids are prepared via late-stage carboxylate exchange of unprotected α-amino acids with [*C]CO2 where *C is 13C, 11C or 14C.

Source: Nature Protocols - March 28, 2024 Category: Biomedical Science Authors: Michael G. J. Doyle Braeden A. Mair Anna Sib Odey Bsharat Maxime Munch Volker Derdau Benjamin H. Rotstein Rylan J. Lundgren Source Type: research