Dynamic duo: Kir6 and SUR in K < sub > ATP < /sub > channel structure and function

Channels (Austin). 2024 Dec;18(1):2327708. doi: 10.1080/19336950.2024.2327708. Epub 2024 Mar 15.ABSTRACTKATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium channel subunits surrounded by four regulatory subunits known as the sulfonylurea receptor, SUR, which confer homeostatic metabolic control of KATP gating. SUR is an ATP binding cassette (ABC) protein family homolog that lacks membrane transport activity but is essential for KATP expression and function. For more than four decades, understanding the structure-function relationship of Kir6 and SUR has remained a central objective of clinical significance. Here, we review progress in correlating the wealth of functional data in the literature with recent KATP cryoEM structures.PMID:38489043 | PMC:PMC10950283 | DOI:10.1080/19336950.2024.2327708
Source: Channels - Category: Molecular Biology Authors: Source Type: research