Prevalence of vaccine-derived poliovirus in sewage waters in Maiduguri, Borno State, Nigeria

Infez Med. 2024 Mar 1;32(1):90-98. doi: 10.53854/liim-3201-12. eCollection 2024.ABSTRACTAfter a long global battle with wild poliovirus, the virus has been defeated through researches and vaccination using the oral polio vaccine and inactivated polio vaccine as well as sensitization. The issue that is now of global concern is that of vaccine-derived poliovirus which emerged from the unstable oral polio vaccine. Ninety sewage water samples were collected from slums in Maiduguri using grab method, concentrated using two phase separation method and subjected to intratypic differentiation and vaccine-derived poliovirus screening. The result revealed the presence of Sabin 1in 17 samples (61.0%) and Sabin 3 in 22 samples (79.0%), all of which were positive after vaccine-derived poliovirus screening. The presence of strains of Sabin 1 and Sabin 3 in the sewage water samples collected is an indication of virus shedding in individuals which could be as a result of vaccination or contact with the faeces infected or vaccinated individuals.PMID:38456020 | PMC:PMC10917565 | DOI:10.53854/liim-3201-12
Source: Infezioni in Medicina - Category: Infectious Diseases Authors: Source Type: research