Efficacy of third-generation epidermal growth factor receptor-tyrosine kinase inhibitors in advanced NSCLC with different T790M statuses tested via digital droplet polymerase chain reaction ddPCR and next-generation sequencing

CONCLUSION: This study indicates that ddPCR may contribute as a supplement to NGS in liquid biopsies for T790M detection in EGFR-TKIs relapsed patients and help to optimize the treatment strategies, especially for those without coexistence of EGFR-sensitive mutation.TRIAL REGISTRATION: www.clinicaltrials.gov identifier is NCT05458726.PMID:38526910 | DOI:10.1080/14737140.2024.2334807
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Authors: Source Type: research