Synthesis of < em > cis < /em > -fused cyclopentenone-pyrrolidine scaffolds < em > via < /em > sequential aza-Piancatelli and Conia-ene type reactions in one pot

Chem Commun (Camb). 2024 Mar 26. doi: 10.1039/d4cc00104d. Online ahead of print.ABSTRACTA novel one-pot protocol that enables sequential execution of an aza-Piancatelli rearrangement and a Conia-ene type reaction has been developed under Lewis acid catalysis. Here, a combination of B(C6F5)3 and Cu(OTf)2, triethylamine, and triphenylphosphine yielded a wide range of cis-fused cyclopentenone-pyrrolidine scaffolds in one pot with good yields and diastereoselectivity.PMID:38529610 | DOI:10.1039/d4cc00104d

Source: Chemical Communications - March 26, 2024 Category: Chemistry Authors: Pooja R Solanke Prakash Kumar Prathama S Mainkar Kiranmai Nayani Srivari Chandrasekhar Source Type: research