Lymphatics-dependent modulation of the sensitization and elicitation phases of contact hypersensitivity

Allergic contact dermatitis is a common inflammatory skin disease comprising of two phases. During sensitization, immune cells are activated by exposure to various allergens, while repeated antigen exposure induces local inflammation during elicitation. Here, we utilized mouse models lacking lymphatics in different skin regions to characterize the role of lymphatics separately in the two phases, using contact hypersensitivity (CHS) as a model of the human disease. Lymphatic-deficient mice exhibited no major difference to single antigen exposure compared to controls.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research