Variability of fibrinolytic activity in pregnant patients exposed to tissue plasminogen activator: an in vitro study utilizing rotational thromboelastometry

Fibrinolysis, the process of breaking down blood clots, plays a crucial role in maintaining hemostasis and preventing excessive clot formation.1 Following coagulation, tissue plasminogen activator (tPA) induces fibrinolysis by converting plasminogen to plasmin which enzymatically cleaves the fibrin clot into fibrin degradation products (FDPs).2 During pregnancy, the maternal fibrinolytic system must be appropriately regulated to accommodate the physiological demands of gestation. However, alterations in the delicate balance of fibrinolysis can occur, leading to conditions such as hyperfibrinolysis, characterized by excessive clot lysis.
Source: International Journal of Obstetric Anesthesia - Category: Anesthesiology Authors: Tags: Short Report Source Type: research