Cancers, Vol. 16, Pages 1281: Patient-Relevant Costs for Organ Preservation versus Radical Resection in Locally Advanced Rectal Cancer
Cancers, Vol. 16, Pages 1281: Patient-Relevant Costs for Organ Preservation versus Radical Resection in Locally Advanced Rectal Cancer
Cancers doi: 10.3390/cancers16071281
Authors:
Georg W. Wurschi
Alexander Rühle
Justus Domschikowski
Maike Trommer
Simone Ferdinandus
Jan-Niklas Becker
Simon Boeke
Mathias Sonnhoff
Christoph A. Fink
Lukas Käsmann
Melanie Schneider
Elodie Bockelmann
David Krug
Nils H. Nicolay
Alexander Fabian
Klaus Pietschmann
Total neoadjuvant therapy (TNT) is an evolving treatment schedule for locally advanced rectal cancer (LARC), allowing for organ preservation in a relevant number of patients in the case of complete response. Patients who undergo this so-called “watch and wait” approach are likely to benefit regarding their quality of life (QoL), especially if definitive ostomy could be avoided. In this work, we performed the first cost-effectiveness analysis from the patient perspective to compare costs for TNT with radical resection after neoadjuvant chemoradiation (CRT) in the German health care system. Individual costs for patients insured with a statutory health insurance were calculated with a Markov microsimulation. A subgroup analysis from the prospective “FinTox” trial was used to calibrate the model’s parameters. We found that TNT was less expensive (−1540 EUR) and simultaneously resulted in a better QoL (+0.64 QALYs) during ...
Source: Cancers - Category: Cancer & Oncology Authors: Georg W. Wurschi Alexander R ühle Justus Domschikowski Maike Trommer Simone Ferdinandus Jan-Niklas Becker Simon Boeke Mathias Sonnhoff Christoph A. Fink Lukas K äsmann Melanie Schneider Elodie Bockelmann David Krug Nils H. Nicolay Alexander Fabian Klaus Tags: Article Source Type: research