Different oncogenes and reproductive histories shape the progression of distinct premalignant clones in multistage mouse breast cancer models

A remote carcinogen exposure can predispose to breast cancer onset decades later, suggesting carcinogen-induced mutations generate long-lived premalignant clones. How subsequent events influence the progression of specific premalignant clones remains poorly understood. Here, we generated multistage mouse models of mammary carcinogenesis by combining chemical carcinogen exposure (using 7,12-dimethylbenzanthracene, DMBA) with transgenes that enable inducible expression of one of two clinically relevant mammary oncogenes: c-MYC (MYC) or PIK3CAH1047R (PIK).

Source: American Journal of Pathology - March 25, 2024 Category: Pathology Authors: Maryknoll Linscott, Jerry Ruizhe Ren, Shelley Gestl, Edward J. Gunther Tags: Regular Article Source Type: research