Biocatalytic enantioselective synthesis of cenobamate, an antiepileptic drug

Chirality. 2024 Apr;36(4):e23660. doi: 10.1002/chir.23660.ABSTRACTA green and efficient process for the synthesis of cenobamate has been accomplished in 70% yield and >99% ee through the bio-reduction of β-ketotetrazole using Daucus carota whole plant cells. The corresponding β-hydroxytetrazole was isolated in 60% yield and >98% ee. This is the first report on the biocatalytic reduction of β-ketotetrazole using plant enzymes derived from D. carota root cells with excellent enantioselectivity.PMID:38511944 | DOI:10.1002/chir.23660

Source: Chirality - March 21, 2024 Category: Molecular Biology Authors: Vennapusa Haritha Pulivarthi Deepthi Rachel Gundamalla Kommu Nagesh Suggala V Satyanarayana Adari Bhaskar Rao Sridhar Balasubramanian Basireddy Venkata Subba Reddy Source Type: research