Ginkgolides with anti-PAF activity from Ginkgo biloba L

Fitoterapia. 2024 Mar 18:105915. doi: 10.1016/j.fitote.2024.105915. Online ahead of print.ABSTRACTFour undescribed ginkgolides, including two rare sesquiterpene ginkgolides (compounds 1 and 2) and two diterpenoid ginkgolides (compounds 3 and 4), were isolated from Ginkgo biloba L. The structures of these four ginkgolides were identified based on extensive spectroscopic analysis, DP4+ probability analysis and X-ray diffraction. Compounds 1 and 2 exhibited excellent antiplatelet aggregation activities with IC50 values of 1.20 ± 0.25 and 4.11 ± 0.34 μM, respectively.PMID:38508499 | DOI:10.1016/j.fitote.2024.105915

Source: Fitoterapia - March 20, 2024 Category: Biochemistry Authors: Jing Zhang Sha Chen Peng Sun Yan Liu Jinzhu Jiang Cong Guo Jintang Cheng Xianju Liu Jun Zhang Chang Chen Jipeng Di An Liu Qingxia Xu Source Type: research