Short-term exposure to cigarette smoke upregulates cathepsin S and alters expression of tight junction ZO-1

Biochimie. 2024 Mar 15:S0300-9084(24)00063-4. doi: 10.1016/j.biochi.2024.03.005. Online ahead of print.ABSTRACTA long-term exposure to cigarette smoke (CS) alters the integrity of airway epithelial barrier, contributes to lung dysfunction, and elicits the expression and activity of lung cathepsin S (CatS), a cysteine protease that participates in the remodeling of connective tissue and cell junctions. Here, we observed that a short-term (4 days) exposure of mice to CS increased the expression and activity of CatS, while the expression level of zonula occludens 1 (ZO-1), an epithelial tight junction protein that stabilizes barrier assembly, was reduced in lung tissue lysates. Present data support that proteolytically active CatS may contribute to the defect of ZO-1 in CS-exposed mice.PMID:38494107 | DOI:10.1016/j.biochi.2024.03.005

Source: Biochimie - March 17, 2024 Category: Biochemistry Authors: Florent Estur Emilie Murigneux Alexis David M élia Magnen Ahlame Saidi Gilles Lalmanach Fabien Lecaille Source Type: research