Artemdubosides A-G, seven unusual polyacetylenes from Artemisia dubia var. subdigitata and their antihepatoma activity

Fitoterapia. 2024 Mar 11;175:105909. doi: 10.1016/j.fitote.2024.105909. Online ahead of print.ABSTRACTArtemdubosides A-E (1-5), the first examples of natural polyacetylenes substituted by 6'-O-crotonyl β-glucopyranoside, and artemdubosides F-G (6-7) that were two unusual polyacetylenes featuring a 6'-O-acetyl β-glucopyranoside moiety, were isolated from Artemisia dubia var. subdigitata. Their structures were elucidated based on the spectral data including HRESIMS, UV, IR, 1D and 2D NMR, and ECD calculations. Antihepatoma assay suggested that compound 1 exhibited activity against HepG2, Huh7, and SK-Hep-1 cells with inhibitory ratios of 77.1%, 90.8%, and 73.1% at 200.0 μM, respectively.PMID:38479615 | DOI:10.1016/j.fitote.2024.105909

Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Yang Ke-Xin Ma Yun-Bao Li Tian-Ze Wang Meng-Fei Li Feng-Jiao Chen Ji-Jun Source Type: research