Endothelial Dysfunction in Psoriasis: An Integrative Review

Vascular endothelial cells (ECs), the inner layer of blood vessels, were previously considered to be a passive lining that facilitates cellular and molecular exchange. However, recent studies have revealed that ECs can respond to various stimuli and actively regulate vascular function and skin inflammation. Specific subtypes of ECs are known to have significant roles in a diverse range of physiological and pathological processes in the skin. This review suggests that EC dysfunction is both causal and consequential in the pathogenesis of psoriasis.

Source: Journal of Investigative Dermatology - March 15, 2024 Category: Dermatology Authors: Qingyang Li, Bingyu Pang, Erle Dang, Gang Wang Tags: Review Source Type: research