Spironolactone metabolite causes falsely increased progesterone in the Abbott Architect immunoassay

CONCLUSIONS: Our investigations are important for individuals who require progesterone measurements using the Architect i2000 immunoassay, especially because it is unlikely for clinicians to order canrenone measurements alongside progesterone measurements for individuals taking spironolactone. Further research is needed to determine whether canrenone can influence progesterone measurements on other immunoassay systems.PMID:38484829 | DOI:10.1016/j.clinbiochem.2024.110747

Source: Clinical Biochemistry - March 14, 2024 Category: Biochemistry Authors: Kwabena A N Sarpong Su Hee Kim Christopher R McCartney Joseph R Wiencek Lindsay A L Bazydlo Source Type: research