Assessment for 11q and other chromosomal aberrations in large B-cell/high-grade B cell lymphomas of germinal center phenotype lacking BCL2 expression

The aggressive B-cell lymphomas include multiple entities with differences in morphology, phenotype, molecular pathogenesis, and clinical behavior. Of the large B cell lymphomas within this category, those that show germinal center (GC) phenotype but lack BCL2 expression include (among others) diffuse large B cell lymphoma, not otherwise specified (DLBCL NOS), a proportion of cases of high-grade B cell lymphoma, NOS (HGBCL, NOS), and high-grade B cell lymphomas with 11q aberration (HGBL-11q, WHO 5th edition).
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research