Alkaloid-metabolites from the mangrove-derived fungus Penicillium robsamsonii HNNU0006

Fitoterapia. 2024 Mar 11;175:105906. doi: 10.1016/j.fitote.2024.105906. Online ahead of print.ABSTRACTNine metabolites, including three undescribed alkaloids pyripyropenes VW (1-2), penicioxa A (4), two previously reported pyripyropene A (3), oxaline (5), three grisephenone-type xanthone derivatives (6-8), and a diphenyl ether derivative 4-chloro-7,4'-dihydroxy-5,2'-dimethoxy-2-methylformate-6'-methybenzophone (9), were isolated from cultures of the mangrove-derived fungus Penicillium robsamsonii HNNU0006. Their structures were determined by spectroscopic analysis, ECD calculations, together with DP4+ probability analysis. Furthermore, all the isolated compounds were tested for cytotoxicity and anti-phytopathogenic fungal activities. Compounds 6-8 showed moderate cytotoxicity against tumor cell lines A549, with IC50 values ranging from 5.68 ± 0.21 to 9.71 ± 0.34 μg/mL, respectively.PMID:38479622 | DOI:10.1016/j.fitote.2024.105906

Source: Fitoterapia - March 13, 2024 Category: Biochemistry Authors: Jing-Wen Wang Yi-Yi Liu Guang-Ying Chen Cai-Juan Zheng Xu-Hua Nong Source Type: research