A myo-inositol dehydrogenase involved in aminocyclitol biosynthesis of hygromycin A

In this study, we verify the activity for one enzyme in this pathway. We show that Hyg17 is a myo-inositol dehydrogenase that has a unique substrate scope when compared to other myo-inositol dehydrogenases. Furthermore, we analyze sequences from the protein family containing Hyg17 and discuss genome mining strategies that target this protein family to identify biosynthetic clusters for natural product discovery.

Beilstein J. Org. Chem. 2024, 20, 589–596. doi:10.3762/bjoc.20.51

Source: Beilstein Journal of Organic Chemistry - March 14, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: aminocyclitol biosynthesis hygromycin A inositol dehydrogenase myo-inositol Full Research Paper Source Type: research