An antiviral oligomerized linear thiopeptide with a nitrile group from soil-derived < em > Streptomyces < /em > sp. CPCC 203702

RSC Adv. 2024 Mar 11;14(12):8260-8263. doi: 10.1039/d4ra01496k. eCollection 2024 Mar 6.ABSTRACTA new linear thiopeptide, bernitrilecin (1), was isolated from Streptomyces sp. CPCC 203702. Compound 1 is the first example of a nitrile-bearing thiopeptide. Its structure and absolute configuration were elucidated by extensive analysis of spectroscopic data and Marfey's method. The biosynthesis of the nitrile unit for 1 was proposed to be through oxidations, decarboxylation, and dehydration. Compound 1 exhibited significant anti-influenza A virus activity with the IC50 value of 16.7 μM.PMID:38469195 | PMC:PMC10925956 | DOI:10.1039/d4ra01496k

Source: Adv Data - March 12, 2024 Category: Epidemiology Authors: Zhe Guo Dewu Zhang Yujia Wang Jinglin Bai Jun Hu Shan Cen Liyan Yu Source Type: research