Deletion of MyD88 in T Cells Improves Antitumor Activity in Melanoma

Cytotoxic CD8+ T cells are central to the antitumor immune response by releasing cytotoxic granules that kill tumor cells. They are activated by antigen-presenting cells, which become activated by DAMPs (damage associated molecular patterns) through MyD88. However, the suppressive tumor microenvironment promotes T-cell tolerance to tumor antigens in part by enhancing the activity of immune checkpoint molecules that prevent CD8+ T-cell activation and cytotoxicity. The authors recently reported that MyD88 limits CD4+ T-cell activation during cardiac adaptation to stress and hypothesized that a similar mechanism exists in CD8+ T cells that could be modulated to improve antitumor immunity.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research