Overcoming Aggregation with Laser Heated Nanoelectrospray Mass Spectrometry: Thermal Stability and Pathways for Loss of Bicarbonate from Carbonic Anhydrase II

Analyst, 2024, Accepted Manuscript DOI: 10.1039/D4AN00229F, PaperJacob S Jordan, Katherine J. Lee, Evan R Williams Variable temperature electrospray mass spectrometry is useful for multiplexed measurements of the thermal stabilities of biomolecules, but the ionization process can be disrupted by aggregation-prone proteins/complexes that have irreversible unfolding... The content of this RSS Feed (c) The Royal Society of Chemistry
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