Tyrosine Kinase Inhibitor-induced Cerebrovascular Occlusion Presenting with Moyamoya Disease-like Stenosis of the Circle of Willis

Intern Med. 2024 Mar 11. doi: 10.2169/internalmedicine.3337-23. Online ahead of print.ABSTRACTVascular occlusive events are notable adverse effects of tyrosine kinase inhibitors (TKIs), which are promising treatments for chronic myeloid leukemia (CML). We herein report the case of a patient with CML who developed cerebrovascular occlusion of the circle of Willis during TKI treatment. Our patient did not meet the diagnostic criteria for moyamoya disease due to the insignificant development of moyamoya vessels. The lack of moyamoya vessel development may be explained by the suppression of tyrosine kinases that are responsible for angiogenesis. Cerebrovascular occlusion of the circle of Willis, without significant development of moyamoya vessels, may be an important phenotype of TKI-associated vasculopathy.PMID:38462515 | DOI:10.2169/internalmedicine.3337-23

Source: Internal Medicine - March 10, 2024 Category: Internal Medicine Authors: Takuya Terakawa Yuya Hayasaka Yuka Umeki Mako Ikeda Yoshiki Matsuoka Masanari Mizuki Shogo Matsui Wataru Nakahara Hitomi Matsunaga Shayne Morris Takeo Nishida Takayuki Sakaki Takeshi Yoshimoto Shuji Ueda Source Type: research