A newly developed UPLC-MS/MS method for simultaneous quantitative analysis of ajuforrestin A, ajuforrestin B, ajugamacrin and 8-O-Acetylharpagide derived from < em > Ajuga < /em > Plants in mice blood and the < em > in vivo < /em > pharmacokinetics

CONCLUSIONS: In this approach, the corresponding pharmacokinetic parameters were successfully clarified in mouse for the first time, which provided a theoretical basis for the improvement of the standard of Ajuga plants and the safety of clinical medication. Furthermore, this method may provide the UPLC-MS/MS evidence for the differentiation of the main close relative varieties of genus Ajuga according to these plants contain different mixtures of the four marker compounds.PMID:38456836 | DOI:10.1080/03639045.2024.2328731
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Authors: Source Type: research