Enantioselective synthesis of tricyclic oxoquinolines < em > via < /em > NHC-catalyzed Michael-aldol-lactamization-dehydration cascade

Chem Commun (Camb). 2024 Mar 6. doi: 10.1039/d4cc00502c. Online ahead of print.ABSTRACTThe enantioselective synthesis of tricyclic oxoquinolines via NHC-catalyzed cascade reaction of enals with malonates bearing a 2-aminophenyl group is reported. The chiral α,β-unsaturated acylazoliums underwent a smooth Michael-aldol-lactamization-dehydration quadruple cascade with the amino malonate derivative to afford the desired tricyclic products.PMID:38445724 | DOI:10.1039/d4cc00502c

Source: Chemical Communications - March 6, 2024 Category: Chemistry Authors: Shilpa Barik Ganga Sankar Akkattu T Biju Source Type: research