Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts

In this large multiethnic epigenome-wide association study of total nicotine equivalents across three cohorts, we identified differential methylation at 408 CpG loci, of which 45 were novel and 51 were externally validated. Our findings highlight the generalizability of these internal smoking dose-related epigenetic modifications across multiple racial and ethnic populations.

Source: The American Journal of Human Genetics - February 16, 2024 Category: Genetics & Stem Cells Authors: Brian Z. Huang, Alexandra M. Binder, Brandon Quon, Yesha M. Patel, Annette Lum-Jones, Maarit Tiirikainen, Sharon E. Murphy, Lenora Loo, Alika K. Maunakea, Christopher A. Haiman, Lynne R. Wilkens, Woon-Puay Koh, Qiuyin Cai, Melinda C. Aldrich, Kimberly D. Tags: Article Source Type: research