Concise total synthesis of (-)-berkelic acid < em > via < /em > regioselective spiroacetal/pyran formation

Chem Commun (Camb). 2024 Mar 5. doi: 10.1039/d4cc00166d. Online ahead of print.ABSTRACTWe successfully developed (1) scalable synthesis of the triol segment and (2) regio- and stereoselective synthesis of the tetracyclic skeleton by tandem spiroacetal/pyran formation from a simpler alkyne precursor, resulting in the achievement of concise total synthesis of (-)-berkelic acid.PMID:38439742 | DOI:10.1039/d4cc00166d

Source: Chemical Communications - March 5, 2024 Category: Chemistry Authors: Shogo Hanada Masahito Yoshida Hideo Kigoshi Source Type: research