Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization

Chem Commun (Camb). 2024 Mar 6. doi: 10.1039/d4cc00129j. Online ahead of print.ABSTRACTThe G-quartet-like supramolecular assembly present in guanosine hydrogel templates macrocyclization between bis-azide and bis-alkyne fragments. The resulting macrocycle enhances viscoelastic properties, and strengthens the hydrogel network. This approach holds potential for the in situ synthesis of drugs and their simultaneous delivery in a stimuli-responsive manner.PMID:38444274 | DOI:10.1039/d4cc00129j

Source: Chemical Communications - March 6, 2024 Category: Chemistry Authors: Binayak Lala Ritapa Chaudhuri Thumpati Prasanth Ines Burkhart Harald Schwalbe Jyotirmayee Dash Source Type: research