Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a translational perspective

Experimental & Molecular Medicine, Published online: 06 March 2024; doi:10.1038/s12276-024-01182-6In the intricate realm of health issues, there’s a serious inflammation-related disorder known as secondary hemophagocytic lymphohistiocytosis, which can escalate to a potentially fatal situation called a cytokine storm. This condition involves the excessive activation of immune cells named macrophages and can lead to signs like constant fever, irregularities in blood cells, and organ enlargement. While sHLH can emerge from various infections and diseases, its precise causes and processes are not completely known, creating a void in our capability to diagnose and treat it effectively. This review is a thorough analysis of sHLH, concentrating on the immune system’s role in the disease and potential treatments. The significance of this research lies in its potential to enhance the diagnosis and management of sHLH, which could result in improved patient outcomes.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author.
Source: Experimental and Molecular Medicine - Category: Molecular Biology Authors: Source Type: research