Cross-regulation of Listeria monocytogenes and the host ubiquitin system in listeriosis

Eur J Cell Biol. 2024 Feb 28;103(2):151401. doi: 10.1016/j.ejcb.2024.151401. Online ahead of print.ABSTRACTThe facultative intracellular bacterium Listeria (L.) monocytogenes may cause severe diseases in humans and animals. The control of listeriosis/L. monocytogenes requires the concerted action of cells of the innate and adaptive immune systems. In this regard, cell-intrinsic immunity of infected cells, activated by the immune responses, is crucial for the control and elimination intracellular L. monocytogenes. Both the immune response against L. monocytogenes and cell intrinsic pathogen control are critically regulated by post-translational modifications exerted by the host ubiquitin system and ubiquitin-like modifiers (Ubls). In this review, we discuss our current understanding of the role of the ubiquitin system and Ubls in listeriosis, as well as future directions of research.PMID:38442571 | DOI:10.1016/j.ejcb.2024.151401

Source: European Journal of Cell Biology - March 5, 2024 Category: Cytology Authors: Yuan Zhuang Johanna B Fischer Gopala Nishanth Dirk Schl üter Source Type: research