Trideuteromethylation of Alkyl and Aryl Bromides by Nickel-Catalyzed Electrochemical Reductive Cross-Electrophile Coupling

Synlett DOI: 10.1055/s-0042-1751558 A new nickel-catalyzed electrochemical, reductive cross-coupling for the trideuteromethylation of alkyl and aryl bromides is reported in which CD3 arenesulfonate derivatives were used as effective and readily available CD3 sources. The CD3-labeled products were obtained with good yields. It was demonstrated that this methodology is scalable and can be efficiently used for various methylations, including 13CH3 and 13CD3 labeling. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - March 4, 2024 Category: Chemistry Authors: Steverlynck, Joost Sitdikov, Ruzal Nikolaienko, Pavlo Kale, Ajit Prabhakar Rueping, Magnus Tags: letter Source Type: research