Similar alterations of the stratum corneum ceramide profile in atopic dermatitis, psoriasis and ichthyosis: results from a systematic review and meta-analysis.

The intracellular lipid matrix of the stratum corneum is critical for the skin barrier function and consists mainly of cholesterol, fatty acids and ceramides (Kihara 2016). Ceramides represent a heterogeneous class of lipids with varying headgroups, carbon chain lengths and degree of unsaturation (Kawana et al. 2020). The composition of the ceramide fraction is altered in atopic dermatitis (AD), psoriasis (PSO) and ichthyosis (ICHT), among other dermatoses (Kihara 2016). Here, we aimed to characterize the similarities between the stratum corneum ceramide profile in these indications using a systematic search strategy and meta-analysis.

Source: Journal of Investigative Dermatology - March 4, 2024 Category: Dermatology Authors: Jannik Rousel, Catherine Mergen, Jan W. Schoones, Tessa Niemeyer-van der Kolk, Martijn B.A. van Doorn, Joke A. Bouwstra, Jeroen van Smeden, Robert Rissmann, the Next Generation ImmunoDermatology Consortium Tags: Letters to the Editor Source Type: research