The Concept of Thromboinflammation

Hamostaseologie. 2024 Feb;44(1):21-30. doi: 10.1055/a-2178-6491. Epub 2024 Feb 28.ABSTRACTInflammation and thrombosis are intricate and closely interconnected biological processes that are not yet fully understood and lack effective targeted therapeutic approaches. Thrombosis initiated by inflammatory responses, known as immunothrombosis, can confer advantages to the host by constraining the spread of pathogens within the bloodstream. Conversely, platelets and the coagulation cascade can influence inflammatory responses through interactions with immune cells, endothelium, or complement system. These interactions can lead to a state of heightened inflammation resulting from thrombotic processes, termed as thromboinflammation. This review aims to comprehensively summarize the existing knowledge of thromboinflammation and addressing its significance as a challenging clinical issue.PMID:38417802 | DOI:10.1055/a-2178-6491

Source: Hamostaseologie - February 28, 2024 Category: Hematology Authors: Waltraud C Schrottmaier Alice Assinger Source Type: research