Radiotherapy Enhances Metastasis Through Immune Suppression by inducing PD-L1 and MDSC in distal sites

CONCLUSIONS: Blockade of PD-L1/CXCL10 axis or MDSC infiltration during radiation can enhance abscopal tumor control and reduce metastasis.PMID:38427437 | DOI:10.1158/1078-0432.CCR-23-3206

Source: Clinical Cancer Research - March 1, 2024 Category: Cancer & Oncology Authors: Yuzhu Hou Kaiting Yang Liangliang Wang Jiaai Wang Xiaona Huang Andras Piffko Sean Z Luo Xinshuang Yu Enyu Rao Carlos Martinez Jason Bugno Matthias Mack Everett E Vokes Sean P Pitroda Steven J Chmura Ralph R Weichselbaum Hua Laura Liang Source Type: research