The promising prospect of human hair follicle regeneration in the shadow of new tissue engineering strategies

Tissue Cell. 2024 Feb 28;87:102338. doi: 10.1016/j.tice.2024.102338. Online ahead of print.ABSTRACTHair loss disorder (alopecia) affects numerous people around the world. The low effectiveness and numerous side effects of common treatments have prompted researchers to investigate alternative and effective solutions. Hair follicle (HF) bioengineering is the knowledge of using hair-inductive (trichogenic) cells. Most bioengineering-based approaches focus on regenerating folliculogenesis through manipulation of regulators of physical/molecular properties in the HF niche. Despite the high potential of cell therapy, no cell product has been produced for effective treatment in the field of hair regeneration. This problem shows the challenges in the functionality of cultured human hair cells. To achieve this goal, research and development of new and practical approaches, technologies and biomaterials are needed. Based on recent advances in the field, this review evaluates emerging HF bioengineering strategies and the future prospects for the field of tissue engineering and successful HF regeneration.PMID:38428370 | DOI:10.1016/j.tice.2024.102338

Source: Tissue and Cell - March 1, 2024 Category: Cytology Authors: Arezoo Karami Vandishi Ali Esmaeili Niloofar Taghipour Source Type: research