Gamma-Secretase Inhibitors Downregulate the Profibrotic NOTCH Signaling Pathway in Recessive Dystrophic Epidermolysis Bullosa

In this study, we further investigated the role of NOTCH signaling in RDEB pathogenesis and explored the effects of its inhibition by γ-secretase inhibitors DAPT and PF-03084014 (nirogacestat).

Source: Journal of Investigative Dermatology - January 16, 2024 Category: Dermatology Authors: Angelo Giuseppe Condorelli, Rebecca Nobili, Anita Muglia, Giorgia Scarpelli, Elisa Marzuolo, Cristiano De Stefanis, Rossella Rota, Andrea Diociaiuti, Rita Alaggio, Daniele Castiglia, Teresa Odorisio, May El Hachem, Giovanna Zambruno Tags: Original Article Source Type: research