Inhibition of Phlpp1 preserves the mechanical integrity of articular cartilage in a murine model of post-traumatic osteoarthritis

Phlpp1 inhibition is a potential therapeutic strategy for cartilage regeneration and prevention of post-traumatic osteoarthritis (PTOA). To understand how Phlpp1 loss affects cartilage structure, cartilage elastic modulus was measured with atomic force microscopy (AFM) in male and female mice after injury.

Source: Osteoarthritis and Cartilage - March 1, 2024 Category: Rheumatology Authors: Katherine M. Arnold, Samantha R. Weaver, Elizabeth L. Zars, Daniel J. Tschumperlin, Jennifer J. Westendorf Source Type: research